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SUMMARY:Polyglutamine Atrophin causes autophagic neurodegeneration by repr
 essing the fat gene - Manolo Fantos\, PhD\, University Lecturer\, MRC Cent
 re for Developmental Neurobiology\, King's College London\, United Kingdom
 .
DTSTART:20101124T120000Z
DTEND:20101124T010000Z
UID:TALK25948@talks.cam.ac.uk
CONTACT:Shannon Tinley-Browne
DESCRIPTION:Polyglutamine Atrophin causes autophagic neurodegeneration by 
 repressing the fat gene\nLarge alterations in transcription accompany neur
 odegeneration in polyglutamine diseases. These pathologies manifest both g
 eneral polyglutamine toxicity and mutant protein specific effects. Here we
  report that the fat tumour suppressor gene mediates neurodegeneration ind
 uced by the polyglutamine protein Atrophin. We have monitored early transc
 riptional alterations in a Drosophila model of Dentatorubral-pallidoluysia
 n Atrophy and found that polyglutamine Atrophins downregulate fat. Fat pro
 tects from neurodegeneration and Atrophin toxicity through the Hippo kinas
 e cascade. The Fat/Hippo signalling alters the autophagic flux in photorec
 eptor neurons\, thereby affecting cell homeostasis. Our data thus provide 
 a crucial insight into the specific mechanism of a polyglutamine disease a
 nd reveal an unexpected neuroprotective role of the Fat/Hippo pathway\, li
 nking tumour suppression and neurodegeneration.
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
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