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SUMMARY:Collective Cell Migration: Leadership\, Invasion and Segregation -
  Dr Alexandre Kabla\, CUED
DTSTART:20101119T140000Z
DTEND:20101119T150000Z
UID:TALK25980@talks.cam.ac.uk
CONTACT:Ms Helen Gardner
DESCRIPTION:A number of biological processes\,  such as embryo development
 \, cancer metastasis or wound healing\, rely on cells moving in concert. T
 he mechanisms leading to the emergence of group motion remain largely unex
 plored. Although biomolecular signalling is known to be involved in most o
 ccurrences of collective migration\, the role of physical and mechanical i
 nteractions has been so far poorly addressed. In this presentation\, a sim
 ple framework for cell motility is implemented in-silico in order to study
  the minimal requirements for the coordination of a group of epithelial ce
 lls\, either as a spontaneously emerging behaviour\, or as a response to "
 leader" cells. It appears that a key parameter\, essentially characterisin
 g the ratio between the cohesion of the tissue and the motile force of ind
 ividual cells\, has the ability to control a wide spectrum of behaviours\,
  from the epithelial-mesenchymal transition to the onset of collective inv
 asion in cancer metastasis. This unified picture allows us to reassess the
  role of biomolecular signalling in a broader context and suggest a novel 
 mechanism for driving cell sorting in remodelling tissues.
LOCATION:Oatley Seminar Room\, Department of Engineering
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