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SUMMARY:Small Molecules and Light as Tools for the Regulation of Biologica
 l Proceeses - Alex Deiters\, North Carolina State University\, USA
DTSTART:20100929T151500Z
DTEND:20100929T170000Z
UID:TALK26128@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The Deiters Lab is developing novel chemical tools for the per
 turbation and investigation of biological processes\, most importantly gen
 e function. Genes are precisely orchestrated in a spatio-temporal fashion\
 ; moreover\, the activity of multiple genes is often wired to each other\,
  thus creating highly complex genetic networks. In order to investigate ge
 nes and gene networks\, regulation with Nature’s level of spatial and te
 mporal resolution must be attained. Two examples of chemical regulation of
  specific biological processes will be presented in this lecture: 1) The d
 evelopment of light-activated oligonucleotides and their application to th
 e photochemical regulation of gene function in mammalian cells and aquatic
  embryos\, and 2) the development of the first small molecule inhibitors o
 f microRNA function and their application as potential anticancer and anti
 viral agents.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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