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SUMMARY:Diffusion in confining geometries - Sergey M. Bezrukov\, National 
 Institutes of Health Bethesda\, MD\, USA
DTSTART:20100905T123000Z
DTEND:20100905T133000Z
UID:TALK26139@talks.cam.ac.uk
CONTACT:Dr. Ulrich Keyser
DESCRIPTION:We explore the consequences of interactions between the pore a
 nd the translocating particles within the framework of a continuum diffusi
 on model for the particle dynamics in the channel.  Several of our finding
 s are quite counter-intuitive (Biophys. J.\, 2005\, 88:L17-L19\; Phys. Rev
 . Lett.\, 2006\, 97:020601\; Phys. Rev. E\, 2009\, 80:020904(R)).  Three o
 f the examples to be discussed in the talk are:  (i) "Sticking" to the cha
 nnel slows down translocation (a particle spends more time in the channel)
  but increases the flux\; (ii) "Uphill" and "downhill" particle translocat
 ion times (and their distributions) are identical\; (iii) An optimal chann
 el should exhibit the most pronounced binding on the side that is opposite
  to the side of the oncoming particles.\n\n
LOCATION:Small Lecture Theatre\, Cavendish Laboratory\, Department of Phys
 ics
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