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SUMMARY:NK cells: effectors of vaccine-induced immunity? - Professor Elean
 or Riley\, London School of Hygiene and Tropical Medicine
DTSTART:20101124T123000Z
DTEND:20101124T133000Z
UID:TALK26167@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Our work concentrates on understanding the cellular and molecu
 lar mechanisms of anti-malarial immunity\, the immunological consequences 
 of malaria infection in endemic and non-endemic populations and immuno-epi
 demiological studies of the relationship between defined immune responses 
 and acquisition of clinically protective immunity. \n\nOur aim is to chara
 cterise the effector mechanisms of both innate and acquired immunity to ma
 laria\, to understand how these mechanisms are induced and how they are re
 gulated in order to promote parasite clearance without inducing immunopath
 ology. \n\nWe also conduct research oriented to the development and evalua
 tion of anti-malarial vaccines\, especially those targeting the asexual\, 
 blood stage of the infection. \n\nCurrent projects include (i) mechanisms 
 of cytokine regulation\, especially the balance between pro-inflammatory c
 ytokines such as IFN-gamma and TNF-alpha and anti-inflammatory cytokines s
 uch as IL-10\,  (ii) investigation of the role of innately activated cellu
 lar immune mechanisms (particularly Natural Killer cells) in resistance to
  malaria infection (iii) induction and maintenance of B and T cell memory 
 to malaria parasites (iv) human genetic variation\, acquired immunity and 
 resistance to severe malarial disease (v) immunological evaluation of the 
 RTS\,S vaccine.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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