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SUMMARY:B lymphocyte regulation of inflammation and autoimmunity - Profess
 or Tom Tedder\, Duke University
DTSTART:20101208T120000Z
DTEND:20101208T130000Z
UID:TALK26168@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Joint Seminar: Immunology in Pathology series and Immunology a
 nd Medicine series \n\nArea of Study:  Structure and function of B lymphoc
 yte cell surface molecules that regulate B cell function\, activation and 
 signal transduction.\n\nOverview:  The focus of our laboratory is the iden
 tification\, structural characterization\, and functional analysis of cell
  surface molecules that regulate B lymphocyte development and function. Ce
 ll surface molecules allow B cells to communicate with the extracellular e
 nvironment by serving as transmembrane regulators\, receptors for soluble 
 factors\, or by mediating cell–cell interactions. Our studies of B-cell
 –associated cell surface receptors\, including CD19\, CD20\, CD21\, CD22
  and CD83\, are aimed at determining how these molecules function\, what t
 heir ligands are\, how they generate transmembrane signals and regulate B 
 cell development\, survival and activation. The role of CD83 in dendritic 
 and B cell biology is also being examined. \n\nThese studies lay the found
 ation for investigating mechanisms of immune dysregulation and the pathoge
 nesis of immune disorders\, such as autoimmunity\, neoplastic transformati
 on\, and immunodeficiency syndromes. We have expertise in cellular immunol
 ogy\, biochemistry\, and molecular biology and are applying a wide range o
 f techniques in determining the function of these molecules. Many of these
  studies depend on the use of transgenic mice which overexpress these regu
 latory molecules or the generation and analysis of knockout mice lacking t
 hese receptors. Current studies are focused on identifying the molecular a
 nd cellular mechanisms by which B cells regulate T cell function and autoi
 mmunity\, with a particular emphasis on a regulatory B cell subset we iden
 tified that controls immune and inflammatory responses. Current studies al
 so focus on identifying the molecular and cellular mechanisms by which CD1
 9\, CD20 and CD22 mAb immunotherapies are effective for treating B cell ma
 lignancies and autoimmunity. \n
LOCATION:Sackler Lecture Theatre (Level 7)\, Cambridge Institute for Medic
 al Research
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