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SUMMARY:Intrinsically Unstructured Proteins: Regulation and Disease - Mada
 n Babu (MRC Laboratory of Molecular Biology)
DTSTART:20110221T160000Z
DTEND:20110221T170000Z
UID:TALK26394@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Altered abundance of several intrinsically unstructured protei
 ns (IUPs)\nhas been associated with perturbed cellular signaling that may 
 lead to\npathological conditions such as cancer. Therefore\, it is importa
 nt to\nunderstand how cells precisely regulate the availability of IUPs. W
 e\nobserved that regulation of transcript clearance\, proteolytic degradat
 ion\,\nand translational rate contribute to controlling the abundance of I
 UPs\,\nsome of which are present in low amounts and for short periods of t
 ime.\nAbundant phosphorylation and low stochasticity in transcription and\
 ntranslation indicate that the availability of IUPs can be finely tuned.\n
 Fidelity in signaling may require that most IUPs be available in\nappropri
 ate amounts and not present longer than needed.\n
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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