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SUMMARY:Retroviral induced pulmonary adenocarcinoma originates from infect
 ion of lung alveolar progenitors - Dr Claudio Murgia\, University of Glasg
 ow
DTSTART:20101201T163000Z
DTEND:20101201T173000Z
UID:TALK26461@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Ovine pulmonary adenocarcinoma (OPA) is caused by Jaagsiekte s
 heep retrovirus (JSRV)\, the causative agent of an infectious lung cancer 
 of sheep with similarities to some forms of human lung cancer. In order to
  determine both the cellular origin and the pathogenesis of OPA\, we analy
 sed the phenotype of the infected and transformed cells at early and late 
 stages of tumour development in experimentally infected lambs and adult sh
 eep. We found that successful JSRV infection of lung cells occurs only in 
 lambs and not in adults. JSRV infection occurs in proliferating type II pn
 eumocytes (expressing the surfactant protein marker\, SP-C) which are 50 t
 imes more abundant in young lambs compared to adult sheep. However\, adult
  sheep subjected to mild lung injury induced by 3 methylindole (3MI)\, and
  subsequently infected by JSRV were fully susceptible to viral infection a
 nd displayed early tumour lesions. These data reinforces the notion that l
 ung adenocarcinoma originate from progenitor alveolar cells. In addition\,
  we showed that JSRV infection of the target cells for viral transformatio
 n occurs only in lambs or in adults after lung injury. This observation is
  in agreement with the common diagnosis of various bacterial\, parasitic o
 r viral infections in naturally occurring OPA cases.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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