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SUMMARY:&quot\;Structural Changes in the brain with Alzheimer's disease.&q
 uot\; - Mark West
DTSTART:20110126T120000Z
DTEND:20110126T130000Z
UID:TALK26600@talks.cam.ac.uk
CONTACT:Shannon Tinley-Browne
DESCRIPTION:One of the cardinal features of Alzheimerâ•˙s disease (AD)
  is amyloidosis \, characterized by an over abundance of beta amyloid (Abe
 ta) in brain tissue\, an increase in the ratio of Abeta42 to Abeta40\, and
  the deposition of Abeta in senile plaques in the brain . It is widely bel
 ieved that this amyloidosis is an early event in a cascade of neurodegener
 ative events that ultimately results in the loss of synapses and neurons a
 nd ultimately in the cognitive decline associated with the disease. In thi
 s talk I will focus on the structural changes that take place in the brain
 s of Alzheimerâ•˙s patients and in transgenic mice that model amyloido
 sis of the type associated with AD. Quantitative measures of the number an
 d size of neuron and synapse observed during the different stages of amylo
 idosis of the Alzheimer type will be presented and discussed in terms of p
 otential mechanisms involved in the development of the disease. 
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
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