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SUMMARY:Intact and Impaired Cognitive Control Processes in Schizophrenia -
  Professor Edward E. Smith - William B. Ransford Professor of Psychology\,
  William B. Ransford Professor of Psychology (in Psychiatry)\, Columbia Un
 iversity.  Chief of Division of Cognitive Neuroscience\, NY State Psychiat
 ric Institute.
DTSTART:20101108T130000Z
DTEND:20101108T140000Z
UID:TALK26635@talks.cam.ac.uk
CONTACT:Nicola Richmond
DESCRIPTION:Deficits of cognitive-control in schizophrenia have been assu
 med to result from a single impairment that leads to widespread consequenc
 es. Contrary to this view\, we hypothesized that different control process
 es operate at different stages of processing\, and that only some of these
  processes may be impaired. We employed two selection tasks to test the hy
 pothesis that patients with schizophrenia have deficits in selecting infor
 mation in working memory (WM)\, but not in selecting perceptual informatio
 n. In the “Ignore” task\, which fosters perceptual selection\, partici
 pants saw a cue to remember either red or blue words\, followed by a memor
 y-set (2 red\, 2 blue)\, a brief delay\, and then a probe. The “Suppress
 ” task was similar\, except the memory-set came before the instruction-c
 ue\, and hence selection had to occur in WM.  We recorded reaction time an
 d percentage errors for positive probes (“Valid”)\, and two kinds of n
 egative probes\, those that were supposed to have been dropped from WM (
 “Lures”) and those that had not appeared in the memory-set (“Control
 s”). Compared to healthy controls\, patients were impaired in the Suppre
 ss but not the Ignore task. This dissociation implies that there are two d
 ifferent selection mechanisms. Further\, the magnitude of patients’ impa
 irment in the Suppress task correlated with measures of their disorganizat
 ion symptoms.
LOCATION:Alternate Mondays (unless otherwise stated)\, 13.05 – 14.00 in 
 the Seminar Room\, Herchel Smith Building\, Forvie Site\, Robinson Way\, A
 ddenbrook's hospital
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