BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:The mitochondrial ABC transporter ATM3 plays a key role in the bio
 genesis of cytosolic Fe-S proteins in Arabidopsis thaliana - Delphine Bern
 ard\, Janneke Balk group
DTSTART:20101203T130000Z
DTEND:20101203T133000Z
UID:TALK26676@talks.cam.ac.uk
CONTACT:15560
DESCRIPTION:Plants are unique in the way Fe-S protein assembly is compartm
 entalized : the ISC pathway is located in mitochondria\, the SUF pathway i
 n chloroplasts and the CIA machinery in the cytosol. To investigate whethe
 r these systems are linked\, and by which compound(s)\, we have functional
 ly characterized the ABC transporters of the mitochondria (ATMs) in the mo
 del plant Arabidopsis thaliana. Arabidopsis has three ATM genes\, namely A
 TM1\, ATM2 and ATM3. Using a collection of mutants\, we show that only ATM
 3 has an important function for plant growth. Analyses of selected metal e
 nzymes showed that the activity of cytosolic aconitase (Fe-S) was strongly
  decreased across the range of atm3 alleles\, whereas mitochondrial and pl
 astid Fe-S enzymes were unaffected. In contrast to mutants in the yeast an
 d mammalian orthologues\, Arabidopsis atm3 mutants did not display a signi
 ficant iron homeostasis defect and did not accumulate iron in mitochondria
 . The putative nature of the substrate of ATM3 and the origin of the chlor
 osis observed in all atm3 mutants will also be discussed. 
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
END:VEVENT
END:VCALENDAR