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SUMMARY:Peptide aptamers as precision tools for dissecting signaling pathw
 ays: application to Nerve Growth Factor signaling - Prof. Brian B. Rudkin 
 CNRS/ENS Universite' Lyon\, France
DTSTART:20110125T130000Z
DTEND:20110125T140000Z
UID:TALK26681@talks.cam.ac.uk
CONTACT:Luca Pellegrini
DESCRIPTION:While systems biology approaches analyzing the genome\, proteo
 me\, interactome etc. are increasing our understanding of complex regulato
 ry networks\, identification of key proteins in signaling pathways that re
 gulate cellular responses remains crucial for furthering our understanding
  of normal cellular processes and pathological perturbations thereof. Pept
 ide aptamers\, conceived to conceptually resemble antibodies\, are small c
 ombinatorial proteins with a constant scaffold presenting a variable regio
 n. Their use for the identification and validation of novel targets and di
 scovery of novel therapeutics in vitro\, in cellular models\, and in vivo 
 in animal models for human disease\, will be discussed. Unpublished result
 s with peptide aptamers towards Ras will be presented regarding their impl
 ementation for the study of Nerve growth factor signaling\, modeling of th
 e structure of the variable loop and binding to RasV12. 
LOCATION:Biochemistry Lecture Theatre\, Sanger Building\, Tennis Court Roa
 d
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