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SUMMARY:Genomes\, Structural Biology and Drug Discovery: What Can Academia
  Contribute? - Emeritus Professor Sir Tom Blundell\, FRS\, Department of B
 iochemistry\, University of Cambridge
DTSTART:20110523T183000Z
DTEND:20110523T200000Z
UID:TALK26802@talks.cam.ac.uk
CONTACT:Dr Nigel Bennee
DESCRIPTION:The knowledge that is now emerging from genomics of man and pa
 thogens and from biochemical\nand structural biology programs has the pote
 ntial to accelerate drug discovery.\n\nGenome sequences\, and most recentl
 y non-synonymous single nucleotide polymorphisms and\nsomatic mutations\, 
 when taken together with structural and functional information on the gene
  products\, can provide insights into the relationship of human genetic va
 riation and disease. This is also helpful in identifying new targets for d
 rug discovery\; it is an exploration of biological space.\n\nHigh-throughp
 ut biophysical and structural analyses can be used to investigate the chem
 ical\nmolecules that proteins might bind\; this is an exploration of chemi
 cal space. I will argue that this is best achieved by structure-guided and
  fragment-screening techniques\, which inform not only lead discovery but 
 also optimization of candidate drug molecules.\n\nMy lecture will describe
  a multidisciplinary approach with physical\, computational\, chemical and
  biological techniques. I will describe recent developments both identifyi
 ng targets and in making new medicines in academia through research progra
 mmes funded by the Gates Foundation\, Wellcome Trust and EU\, co-funded by
  collaborations with big pharma and through forming a spin-out company (As
 tex) from our Cambridge lab. I will discuss applications in HIV\, cancer a
 nd TB
LOCATION:Wolfson Lecture Theatre\, Churchill College\, Storey's Way\, Camb
 ridge
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