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SUMMARY:Many ways to make ends meet: orchestration of DNA double-strand br
 eak repair processes by the NHEJ pathway - Prof. Aidan Doherty - Genome Da
 mage &amp\; Stability Centre\, University of Sussex.
DTSTART:20110310T143000Z
DTEND:20110310T153000Z
UID:TALK26815@talks.cam.ac.uk
CONTACT:Becky Baglow
DESCRIPTION:Non homologous end-joining (NHEJ) is an essential DNA double-s
 trand break (DSB) repair pathway required to maintain genome stability. We
  are using model unicellular organisms (bacteria and yeast)\, combined wit
 h biochemical and structural approaches\, to understand both the mechanism
  and regulation of the NHEJ pathway. The simplicity of these DSB repair co
 mplexes makes them ideal models for studying both the cellular and molecul
 ar mechanisms that co-ordinate the processing and joining of DSBs by the N
 HEJ pathway and also provides a conceptual framework for understanding rel
 ated break repair processes in higher eukaryotes. \n\nReferences: \nWeller
  et al. (2002) Science 297\, 1686-1689.\nDella  et al.  (2004) Science 306
 \, 683-685.\nHentges et al. (2007) J. Biol. Chem. 281\, 37517–37526.\nPi
 tcher et al. (2007) Ann. Rev. Microbiol. 61\, 258-282.\nBrissett et al. (2
 007) Science 318\, 456-459.\n\n\n\n\n
LOCATION:Part II room\,  Department of Genetics
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