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SUMMARY:Information and Noise in Cell-Specific Gene Expression - Prof. Edo
  Kussell\, Department of Biology\, New York University\, USA
DTSTART:20100930T151500Z
DTEND:20100930T160000Z
UID:TALK26832@talks.cam.ac.uk
CONTACT:M. Madan Babu
DESCRIPTION:Advances in biological understanding are increasingly reliant 
 on quantitative modeling and theory that capture critical aspects of biolo
 gical phenomena. In developmental biology and in the study of cellular dyn
 amics\, quantitative data are available on the activity of genes in indivi
 dual cells or cell-type samples.  But how should we formalize the intuiti
 ve concept of cell-type specificity? This talk presents measurements of ce
 ll-type specificity based on the amount of information that a gene?s level
  of expression provides about the identity of the cell. The approach is ap
 plied to global cell-type specific data available in the Arabidopisis root
  and the mouse\nbrain\, revealing the modular structure of multicellular t
 ranscriptomes involved in tissue patterning.  Applications to biomarker d
 iscovery and treatment-specific data sets will also be discussed.
LOCATION:MRC LMB: Cell Biology Seminar Room (Level 4\, Room 4014)
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