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SUMMARY:Transcriptional Regulation of Cell State - Richard Young\, Whitehe
 ad Institute for Biomedical Research and M.I.T.
DTSTART:20111020T120000Z
DTEND:20111020T130000Z
UID:TALK27047@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Discovering how transcriptional regulation establishes and mai
 ntains gene expression programs in mammalian cells is important for unders
 tanding the control of cell state\, the process of development and the mec
 hanisms involved in various diseases.  Embryonic stem cells (ESCs) provide
  a powerful model system for studying transcriptional regulation in early 
 development.  I will describe the key features of transcriptional regulato
 ry circuitry that have emerged from studies in ESCs\, including the roles 
 that specific transcription factors\, cofactors and chromatin regulators p
 lay in the establishment and maintenance of pluripotency and self-renewal.
   Advances in our understanding of the regulation of cellular gene express
 ion programs are providing new insights into the mechanisms that contribut
 e to a variety of diseases and are influencing development of therapeutics
  for these diseases.  \n\n
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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