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SUMMARY:Analysis of synaptic connectivity and function in the cerebellum i
 n vivo - Prof Henrik Jörntell\, Lund University\, Sweden
DTSTART:20101104T160000Z
DTEND:20101104T170000Z
UID:TALK27582@talks.cam.ac.uk
CONTACT:Christian Scheppach
DESCRIPTION:An understanding of brain function requires knowledge of the n
 umbers and types of constituent neurons\, the information processing carri
 ed out by each neuron and the connectivity pattern or synaptic weight dist
 ribution by which the neurons are interconnected. With this information at
  hand it is possible to reconstruct the function and computational propert
 ies of the different parts of the neuronal circuitry as well as the potent
 ial functional impact of plasticity at specific synapses.\n\nFor the cereb
 ellar subsystem involved in arm-hand movement control (the C3 zone and the
  anterior interposed nucleus)\, much of this type of information has gradu
 ally become available. Nearly 50 years of studies using classical neuroana
 tomical and electrophysiological  techniques has laid an important foundat
 ion for understanding and systematizing the overall connectivity of this s
 ystem. With the _in vivo_ whole cell patch clamp recording technique\, we 
 have been able to combine this background knowledge with an intracellular 
 analysis of synaptic weight distribution and input-output conversions of t
 he neurons in response to natural patterns of synaptic input. In the talk\
 , I will present and discuss our ambition to reach a circuitry-level under
 standing of this brain subsystem.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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