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SUMMARY: Long- and short-range gene regulation: from genome-wide patterns 
 of sequence conservation to the dynamics of regulatory complexes - Boris L
 enhard Department of Biology\, University of Bergen\, Norway
DTSTART:20101028T130000Z
DTEND:20101028T140000Z
UID:TALK27726@talks.cam.ac.uk
CONTACT:Sarah Teichmann
DESCRIPTION:The accumulation of data on highly-conserved long-range enhanc
 ers\, as well as the genome wide transcription factor binding and epigenet
 ic modification data from ChIP experiments\, has begun to dismantle the te
 xtbook picture of transcriptional regulation by transcription factors bind
 ing to either proximal promoter regions or distal upstream enhancers. High
 ly conserved enhancers of developmental genes can drive the expression of 
 their target genes from megabase distances\, often with one or more unaffe
 cted genes in between. As the ChIP-seq data confirms\, transcription facto
 rs are often found to bind inside long introns\, especially the first intr
 on of metazoan genes that is also the longest on average. At the same time
 \, many expression patterns of tissue-specific genes can still be recapitu
 lated using only its short upstream sequence pit in front of a reporter ge
 ne.  We have investigated  the distribution  of binding locations of regul
 atory complexes driving expression of different functional categories of g
 enes and the effect of their position on the activity of their target gene
 s and other genes in their neighborhood. The results indicate that the res
 ponsiveness of genes to long-range regulation strongly depends on the type
  of their  core promoter and represents a defining property of several fun
 ctionally distinct classes of genes. This helps explain the evolutionary p
 atterns of gene and genome duplications\, and has implications for the pla
 nning and interpretation of studies of gene regulation and genome-wide dis
 ease association. \n\n
LOCATION:Structural Studies Seminar Rm\, MRC Lab Molec Biol
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