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SUMMARY:Mathematical models of signaling networks  and their application t
 o disease - Julio Saez-Rodriguez (EBI)
DTSTART:20101201T140000Z
DTEND:20101201T150000Z
UID:TALK28259@talks.cam.ac.uk
CONTACT:Danielle Stretch
DESCRIPTION:Cells are equipped with complex molecular networks that proces
 s\nexternal information\, allowing cells to react to their environment.\nD
 eregulation of this signal transduction system is involved in the\ndevelop
 ment of a variety of diseases such as diabetes and cancer. In\nmy talk I w
 ill discuss how to study these molecular networks  using a\ncombination of
  high-throughput proteomics and mathematical modelling.\nAs a case study\,
   I will show an application to hepatocellular\ncarcinoma\, the most frequ
 ent form of liver cancer.  Mathematical\nmodels specific for healthy liver
  cells and hepatocellular carcinoma\ncell lines were generated and compare
 d\, revealing three key\ndifferences in the wiring of their signalling pat
 hways. These\ndifferences are potential targets for new therapies. 
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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