BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Optimal micro patterning of a collagen scaffold coordinates the in
 duction of morphogenetic pathways in adult nerve regeneration - Dr. Alessa
 ndro Sannino\,PhD\, Associate Professor of Polymer Technology and Biomater
 ials\, University of Salento\, Lecce\, Italy.
DTSTART:20101213T140000Z
DTEND:20101213T150000Z
UID:TALK28262@talks.cam.ac.uk
CONTACT:Shannon Tinley-Browne
DESCRIPTION:Various therapeutic approaches are applied to patients sufferi
 ng from peripheral nerve injuries with only partial success so far\, in te
 rms of both quality as well as extent of regeneration and re-innervation. 
 We have previously developed a micro-patterned collagen scaffold (MPCS) wi
 th a peculiar radially aligned porosity of the tube wall\, and predicted t
 hat its microstructure might play a significant role in the regulation of 
 cellular and molecular mechanisms sustaining cell behaviour inside the sca
 ffold and\, in turn\, improving distal induced regeneration. Here we teste
 d in vivo the clinico-pathological impact of this MPCS over a 10-mm critic
 al size defects in the adult rat sciatic nerve. Neurophysiological and mor
 phological data demonstrate physiological sciatic nerve regeneration in MP
 CS-implanted transected rats\, as compared to as compared to transected ra
 ts implanted with either clinical-grade collagen tubes\, or with silicone 
 tubes. Whole genome gene expression analyses confirm MPCS-specific remarka
 ble coordinated induction of clusters of genes responsible for cell prolif
 eration\, motility and myelination. We here establish the dynamics of the 
 major cellular and molecular pathways regulating the effects of this novel
  MPCS on physiological peripheral nerve regeneration. Our findings open ne
 w perspectives towards the clinical application of this micropatterned sca
 ffold\, owing to its ease of production\, cost-effectiveness\, favorable d
 egradation rate and remarkable cell-instructing behavior.\n
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
END:VEVENT
END:VCALENDAR