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SUMMARY:Towards Automation of Protein NMR - Babak Alipanahi
DTSTART:20101210T100000Z
DTEND:20101210T110000Z
UID:TALK28343@talks.cam.ac.uk
CONTACT:Microsoft Research Cambridge Talks Admins
DESCRIPTION:Protein structure is the key to deciphering its function and b
 iological role.  Nuclear Magnetic Resonance (NMR) spectroscopy is one of t
 he major experimental protein structure determination methods. Manual NMR 
 process is cumbersome and\ntime-consuming\, and there is a great need to a
 utomate this process.  Therefore\, a plethora of research is conducted on 
 developing computational tools that aim to fully-automate the NMR process.
   Although protein NMR is shown to be a\npromising method for studying str
 uctural aspects of a protein (i.e. protein folding)\, it is limited to sma
 ll proteins. Several issues emerge when the NMR method is applied to large
  proteins: (a) numerous overlapping signals make identifying\nindividual s
 ignals challenging\; and (b) the signals become broader and weaker to the 
 extent of becoming almost undetectable. In this talk\, I will describe a n
 ovel approach to developing a fully-automated protein NMR method for large
 r proteins\, and present the five modules I have designed and developed fo
 r the automation of NMR pipeline.\n
LOCATION:Small lecture theatre\, Microsoft Research Ltd\, 7 J J Thomson Av
 enue (Off Madingley Road)\, Cambridge
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