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SUMMARY:'Mitochondrial release factors: a family or just good friends?' - 
 Dr Zofia Chrzanowska-Lightowlers\, University of Newcastel
DTSTART:20110202T150000Z
DTEND:20110202T160000Z
UID:TALK28397@talks.cam.ac.uk
CONTACT:Penny Peck
DESCRIPTION:Human mitochondria contain their own genome that is transcribe
 d and all the mt-mRNAs so produced translated\, within the organelle. Ther
 e is a specific machinery required for intraorganellar protein synthesis t
 hat has similarities and differences to that of bacteria and the eukaryoti
 c cytosol. The proteins that are involved in the termination step that fac
 ilitates release of the nascent peptide are of particular interest. These 
 so called release factors (RF) need to be able to discriminate between seq
 uences in the ribosomal A-site and recognize which are STOP codons. On int
 eraction with the ribosome the RF changes conformation and facilitates hyd
 rolysis of the ester bond that anchors the newly made protein to the final
  tRNA. Bioinformatic searches have now revealed a family of 4 predicted hu
 man mitochondrial release factors\, with ICT1 and C12orf65 added to the pr
 eviously described mtRF1 and mtRF1a. Intriguingly\, these 2 new members\, 
 ICT1 and C12orf65\, both lack the 2 regions involved in codon recognition 
 and are therefore unlikely candidates for RNA triplet recognition.\n
LOCATION:Sackler Lecture Theatre (Level 7)\, Wellcome Trust/MRC Building\,
  Addenbrooke's Site
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