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SUMMARY:Probing lymphocyte activation using single chain MHC class I molec
 ules - Dr Keith Gould\, Imperial College London
DTSTART:20110202T123000Z
DTEND:20110202T133000Z
UID:TALK28706@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Dr Gould has worked in the field of antigen presentation by ma
 jor histocompatibility complex (MHC) class I molecules for the past 25 yea
 rs\, initially at the Sir William Dunn School of Pathology in Oxford\, and
  since 1996 at Imperial College London\, St Mary's campus. \n\nCurrent res
 earch focusses on exploiting the special properties of single chain MHC cl
 ass I molecules\, in which the three normally separate components of prese
 nted peptide\, beta2-microglobulin and class I heavy chain are covalently 
 joined together via flexible linker sequences. This type of construct allo
 ws manipulation of class I molecules for various purposes\, and in collabo
 ration Dr Gould has used single chain MHC class I molecules to investigate
  the delivery of signals to CD8+ T lymphocytes and natural killer cells. \
 n\nThe properties of single chain MHC class I molecules and recent researc
 h data will be presented.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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