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SUMMARY:From impulsivity to compulsivity: cross-species studies in humans 
 and other animals relevant to neuropsychiatric disorders - Trevor Robbins 
 (Dept of Experimental Psychology)
DTSTART:20110214T160000Z
DTEND:20110214T173000Z
UID:TALK28727@talks.cam.ac.uk
CONTACT:Mandy Carter
DESCRIPTION:This lecture will focus on the utility of the impulsivity and 
 compulsivity constructs for addiction\, attention deficit/hyperactivity di
 sorder (ADHD) and obsessive-compulsive disorder OCD )\, based on analyses 
 of their neuropsychological and neurochemical basis in humans and in other
  species. Evidence will be reviewed for striatal and prefrontal cortical c
 omponents of these potential neural endophenotypes\, as well as their diff
 erential chemical modulation by the ascending arousal systems\, including 
 the monoamines and acetylcholine. Evidence will be drawn from studies usin
 g techniques ranging from functional and structural MR\, positron emission
  tomography\, selective lesions\, intra-cerebral infusions and systemic ps
 ychopharmacology. These methods are used to study performance in tasks mea
 suring different forms of impulsivity\, including the stop-signal task\, a
 s well as tests of compulsivity including reversal learning and extra-dime
 nsional set-shifting. The overall theme of the lecture is to illustrate ho
 w work in basic cognitive and behavioural neuroscience may be translated i
 nto the clinical context.\n\nReferences\n\nEveritt BJ\, Robbins TW (2005) 
 Neural systems of reinforcement for drug addiction: from actions to habits
  to compulsion. Nature Neuroscience 8\, 1481-1489\n\nRobbins TW (2007). Sh
 ifting and stopping: fronto-striatal substrates\, neurochemical modulation
  and clinical implications. Philosophical Transactions of The Royal Societ
 y B\, 362\, 917-932
LOCATION:Seminar Room\, MRC Cognition and Brain Sciences\, 15 Chaucer Road
 \, Cambridge
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