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SUMMARY:Imaging prions: the intracellular site of conversion and the mecha
 nism of intercellular spreading - Dr Chiara Zurzolo\, Unité de Trafic Mem
 branaire et Pathogénèse\, Institut Pasteur\, Paris.
DTSTART:20110407T110000Z
DTEND:20110407T120000Z
UID:TALK28777@talks.cam.ac.uk
CONTACT:Shannon Tinley-Browne
DESCRIPTION:Prion diseases are fatal\, neurodegenerative disorders in huma
 n and animals\, characterized by the  accumulation of an abnormally folded
  isoform of the cellular prion protein (PrPC)\, denoted PrPSc. The  mechan
 ism of PrPC to PrPSc conversion is not known but it comprises changes in P
 rPC structure and  biochemical properties. It is also not known where the 
 conversion process occurs inside the cells\, and which trafficking pathway
 s allow the encounter and the conversion of PrPC into PrPSc. Furthermore\,
  it is  still a mystery how PrPSc invades the CNS from the periphery and w
 hich mechanisms allow prions to  spread from cell to cell.\nWe are current
 ly analysing both the mechanisms of prion conversion and of prions spreadi
 ng and I will  focus my talk on two recent findings of the lab: 1) prion c
 onversion occurs/involves the endosomal  recycling compartment (Marjianovi
 c et al\, PloS Path 2009)\, and 2) tunnelling nanotubes are involved in th
 e transfer PrPSc between different cells (Gousset et al\, NCB 2009). 
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
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