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SUMMARY:Structural insights into the initiation of DNA synthesis in eukary
 otic replication - Dr. Luca Pellegrini\, Department of BIochemistry\, Univ
 ersity of Cambridge
DTSTART:20110209T103000Z
DTEND:20110209T113000Z
UID:TALK28938@talks.cam.ac.uk
CONTACT:Dr Alfonso De Simone
DESCRIPTION:DNA polymerases need a primer to begin the synthesis of new DN
 A\nduring replication. Nature has evolved specialised polymerases\, termed
  primases\, that are able to synthesise short RNA primers de novo. Because
  of the antiparallel nature of the DNA double helix\, replication must sta
 rt at least once on the leading strand and multiple times on the lagging s
 trand. Thus\, the enzymatic activity of the primase is constantly required
  at the replication fork. Our understanding of the molecular mechanisms by
  which primases synthesise the RNA primer is not well understood. In the t
 alk\, I will discuss our recent efforts to understand structure and functi
 on of the DNA Pol alpha/primase complex\, responsible for initiation of DN
 A synthesis in eukaryotic replication.\n
LOCATION:Unilever Lecture Theatre\,  Department of Chemistry
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