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SUMMARY:Modelling cell migration and adhesion during development - R.N. Th
 ompson\, University of Oxford
DTSTART:20110114T163000Z
DTEND:20110114T173000Z
UID:TALK29071@talks.cam.ac.uk
CONTACT:Prof. Julia Gog
DESCRIPTION:Cell migration and adhesion are essential processes that take 
 place during development. Cells migrate to their target sites\, and cell-t
 o-cell adhesion enables cells to aggregate and form cohesive tissues. Both
  are crucial\, not only for the proper development of the body structure a
 nd organs\, but also for tissue homeostasis and repair\, and for the invas
 ion of cancerous tumours. Mathematical modelling and numerical simulation 
 provides a means to explore current hypotheses for the roles of migration 
 and adhesion: to put them into a concrete framework where they may be test
 ed and refined\, and experimentally testable predictions made.\n\nWe consi
 der a one-dimensional stochastic\, lattice-based model of cell-to-cell adh
 esion. We examine behaviour at the mesoscopic individual cell level\, but 
 also look at the average macroscopic behaviour of the system. We also cons
 ider how to implement this model on a growing domain (as in development) 
 – finding that the traditional box-splitting method for domain growth pr
 esents several problems\, we develop our own growth simulation method. 
LOCATION:Centre for Mathematical Sciences\, MR15
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