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SUMMARY:Stem Cells and Tissue Homeostasis - Dr 
Kim 
Jensen\, 
Anne 
 
McLaren 
Laboratory 
for 
Regenerative 
Medicine
DTSTART:20110127T160000Z
DTEND:20110127T170000Z
UID:TALK29195@talks.cam.ac.uk
CONTACT:Christian Scheppach
DESCRIPTION:Maintenance of adult tissues is carried out by stem cells and 
 is sustained throughout life in a highly ordered manner. Homeostasis withi
 n the stem cell compartment is governed by positive and negative feedback 
 regulation of instructive extrinsic and intrinsic signals. Stem cells resp
 ond to these signals by generating progeny to maintain the steady state of
  the tissue and carry out tissue repair following injury. Too much or too 
 little proliferation within the stem cell compartment will have devastatin
 g consequences for long-term tissue maintenance. We have identified a mark
 er of somatic stem cells in various epithelial tissues such as the epiderm
 is. Using mouse models in combination with in vitro cells culture techniqu
 es we demonstrate that the protein is required for homeostasis via regulat
 ion of growth factor responsiveness in the stem cell compartment. This has
  implications on the role of growth factor signalling and negative feedbac
 k regulation in tissue development\, maintenance and progression of malign
 ant disease.\n
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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