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SUMMARY:Physiological and pathological plasticity in identified hippocampa
 l inhibitory interneurons - Dr
 Karri 
Lamsa\,
 Dept 
of 
Pharma
 cology\, 
Univ 
of 
Oxford
DTSTART:20110310T160000Z
DTEND:20110310T170000Z
UID:TALK29201@talks.cam.ac.uk
CONTACT:Christian Scheppach
DESCRIPTION:Hippocampal inhibitory neuronal network consists of specialize
 d GABAergic interneuron types with distinct anatomical properties. Certain
  interneurons express activity-induced lasting plasticity by and large sim
 ilar to long-term potentiation (LTP) and –depression (LTD) in principal 
 cells. However\, plasticity in GABAergic inhibitory network is more divers
 e than in principal cells. Four different long-term plasticity forms are e
 licited by specific activity patterns in the hippocampal CA1 area. Anatomi
 cal analyses demonstrate that plasticity is specific to interneuron type.\
 n\nDegenerative brain diseases may also be associated with cell type-speci
 fic changes in GABAergic inhibitory interneuron population. We have looked
  into properties of hippocampal circuits in mice which over-express a comm
 on schizophrenia risk gene neuregulin-1 (NRG1). NRG1 and its receptor ErbB
 4 play a role in the formation and maturation of inhibitory GABAergic circ
 uits. NRG1 transgenic mice show impaired working memory. In addition recor
 dings in hippocampal slices reveal distorted gamma (20-80 Hz) oscillation 
 and altered GABAergic inhibition. We have used optical stimulation of ligh
 t-gated channel channelrhodopsin-2 selectively expressed in interneuron ax
 ons to uncover the mechanisms underlying changed inhibition.\n\nWe suggest
  that changes restricting to distinct interneuron types have different imp
 acts in hippocampal network function.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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