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SUMMARY:Electrochemical detection in nanochannels: a new single-molecule t
 echnique - Prof. Searge J. G. Lemay\, University of Twente\, The Netherlan
 ds
DTSTART:20110318T140000Z
DTEND:20110318T150000Z
UID:TALK29445@talks.cam.ac.uk
CONTACT:Erika Eiser
DESCRIPTION:We have developed a new single-molecule detection technique ba
 sed on electrochemical detection at pairs of metal electrodes imbedded in 
 a nanochannel. The target molecules are electrochemically active and free\
 nto diffuse in the 50 nm high\, water-filled channel separating the electr
 odes. As a direct consequence of the tiny volumes involved\, equilibrium s
 tatistical fluctuations in the number of molecules present\ninside the dev
 ices can be observed with the "naked eye" as electrical noise. This mesosc
 opic effect is the electrochemical equivalent of Fluorescence Correlation 
 Spectroscopy (FCS)\, and serves as a microscopic probe of the adsorption d
 ynamics of the target molecules. Recently\, we have managed to further boo
 st sensitivity so as to reach the ultimate\nlimit: the electrical detectio
 n of individual small molecules in solution.
LOCATION:Pippard Lecture Theatre\, Cavendish Laboratory
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