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SUMMARY:Transcription and R-loops as a source of genome instability - Andr
 és Aguilera\, University of Seville
DTSTART:20110208T161500Z
DTEND:20110208T180000Z
UID:TALK29522@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:A number of eukaryotic factors working at the interface\ntrans
 cription-RNA export plays a role in preventing R-loop formation\, one key 
 substrate in the origin of transcription-associated genome instability\, w
 hich may be triggered by DNA modifying enzymes such as AID. I will present
  our recent work trying to understand the interconnection between transcri
 ption\, R-loops and genome instability in yeast and human cells at a genom
 e-wide scale\, the impact that replication may have in this interconnectio
 n\, and how it can result in translocations often associated with cancer.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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