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SUMMARY:'Pathogenic'\, 'Protective' and 'Plastic': So what is a Th17 cell?
  - David Bending\, Department of Pathology\, University of Cambridge
DTSTART:20110216T123000Z
DTEND:20110216T133000Z
UID:TALK29717@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:"Together with the well-established Th1 and Th2 effector subse
 ts\, Th17 cells are widely considered to be a third lineage of effector T 
 helper cells.  Since their discovery\, a large body of evidence quickly gr
 ew that suggested a pathogenic role for these inflammatory cells in many m
 ouse-models of autoimmune conditions\, such as in experimental autoimmune 
 encephalomyelitis (EAE) and Collagen-induced arthritis (CIA). \n\nOur init
 ial work assessed the ability of Th17 cells to be pathogenic in an adoptiv
 e transfer model of type one diabetes.   We found that in vitro generated 
 Th17 cells could transfer type one diabetes (T1D)\, but showed that this w
 as due to their conversion to a Th1-like profile\, and was dependent on th
 e production of IFNg. \n\nFollowing this work\, some controversies have su
 rfaced about the nature of Th17 cells in humans and in mice\, about how th
 ey may be differentiated in vitro and around the lack of analysis of Th17 
 cells generated in vivo.   We have used an epigenetic approach to analyse 
 purified populations of Th17 cells generated  in vitro and also in vivo (e
 ither naturally or in a model of intestinal inflammation involving infecti
 on with Helicobacter hepaticus)  to further understand their apparent line
 age flexibility.  \n\nThe data presented will aim to resolve some of the c
 ontroversies in the murine field of Th17 cells\, whilst also speculating a
 bout what a Th17 cell may be\, and what roles such cells may play in the i
 mmune system."\n
LOCATION:Seminar Room\, Department of Pathology\, Tennis Court Road
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