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SUMMARY:The Cellular Basis for the Cancer-Related Phenomena of Immune Supp
 ression and Cachexia - Doug Fearon
DTSTART:20110331T151500Z
DTEND:20110331T170000Z
UID:TALK30070@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Although cancers elicit immune responses\, they occur. This pa
 radox must be understood to improve cancer immunotherapy. “Stromal” ce
 lls (all non-cancer cells in the tumor) prevent cancer-specific immune res
 ponses from controlling tumor growth\, but the diversity of this populatio
 n has hindered identification of the relevant cell type.  We developed a m
 ouse model that enables the conditional ablation of a stromal cell type th
 at was recognized 20 years ago by its expression of the membrane protein\,
  “fibroblast activation protein-alpha”\, or FAP.  Ablating FAP+ stroma
 l cells causes immune-mediated necrosis of established tumors. FAP+ cells 
 reside also in skeletal muscle where their depletion leads to a wasting co
 ndition resembling cancer cachexia.  Thus\, the redistribution of the FAP+
  cell from normal tissues to tumors may link the cancer-related phenomena 
 of immune suppression and cachexia. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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