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SUMMARY:Milstein Lecture 2011: How the endoplasmic reticulum gets into sha
 pe - Tom Rapoport\, Harvard Medical School
DTSTART:20110407T151500Z
DTEND:20110407T170000Z
UID:TALK30071@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:How is the characteristic shape of a membrane-bound organelle 
 achieved? We have addressed the mechanism by which the morphology of the e
 ndoplasmic reticulum (ER) is generated. ER tubules are shaped by two famil
 ies of integral membrane proteins\, the reticulons and DP1/Yop1p\, which a
 re necessary and sufficient for tubule formation. These proteins may use h
 ydrophobic insertion and scaffolding mechanisms to shape lipid bilayers in
 to tubules. The interconnection of ER tubules in mammalian cells requires 
 the atlastins\, membrane-bound GTPases of the dynamin family\, which proba
 bly promote homotypic fusion of the tubules. A similar GTPase in yeast\, S
 ey1p\, may have an analogous function. Our recent results suggest that the
  reticulons and DP1/Yop1p are also a major determinant of peripheral ER sh
 eets\, which can be further stabilized by sheet-promoting proteins
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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