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SUMMARY:Mitochondrial Reactive Oxygen Species: Signals or Stresses? - Prof
 essor Paul Schumacker\, Northwestern University\, Chicago\, USA
DTSTART:20110323T150000Z
DTEND:20110323T160000Z
UID:TALK30347@talks.cam.ac.uk
CONTACT:Penny Peck
DESCRIPTION:Mitochondria have been known to generate reactive oxygen speci
 es (ROS) for nearly fify years.  Initially viewed as toxic byproducts of t
 he electron transport chain\, these oxidants have been implicated in a wid
 e range of human diseases.  However\, most clinical trials of antioxidant 
 therapies have failed to attenuate disease progression or pathogenesis.  M
 ore recent studies reveal that spatial organization of ROS generation occu
 rs in healthy and diseased cells\, and that some mitochondrial ROS play im
 portant roles in signaling cell stress and activating protective responses
 .  This talk will examine these disparate roles for mitochondrial ROS\, an
 d describe new approaches to assessing intracellular oxidant stresses in h
 ealth and disease.
LOCATION:Sackler Lecture Theatre (Level 7)\, Wellcome Trust/MRC Building\,
  Addenbrooke's Site
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