BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Exosome secretion and communication between tumors and the immune 
 system - Clotilde Thery
DTSTART:20110622T110000Z
DTEND:20110622T120000Z
UID:TALK30470@talks.cam.ac.uk
CONTACT:Shannon Tinley-Browne
DESCRIPTION:Exosomes are small membrane vesicles secreted in the extracell
 ular medium by various cell types\, including tumor and immune cells. They
  are produced inside the cells in endocytic multivesicular compartments\, 
 and released when these compartments fuse with the plasma membrane. Exosom
 es purified in vitro from tumor cell lines have been shown to modulate imm
 une responses in various ways\, inhibiting or enhancing them\, depending o
 n the experimental systems used. In vivo\, exosomes or vesicles bearing tu
 mor markers have been found in the serum of cancer patients or tumor-beari
 ng mice\, but the role played by such tumor-derived exosomes in vivo remai
 ns unclear. \nTo answer this question\, our approach is to identify intrac
 ellular molecules specifically involved in the exosome secretion machinery
 . Using a library of shRNA\, we have recently shown a crucial role of two 
 small Rab GTPases in exosome secretion by the human HeLa tumor cell line. 
 We are now using tools to inhibit these particular Rabs in mouse tumor cel
 ls\, in order to determine whether (1) the molecular machinery involved in
  exosome secretion is conserved in different human and mouse cell types\, 
 and (2) how inhibiting specifically the secretion of exosomes by tumor cel
 ls affects growth and immune responses generated in vivo by these tumors.\
 n
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
END:VEVENT
END:VCALENDAR