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SUMMARY:Adult stem cell fate: a laboratory for statistical physics - Ben S
 imons (University of Cambridge)
DTSTART:20110919T150000Z
DTEND:20110919T160000Z
UID:TALK30645@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:In adult\, tissues are maintained and repaired by stem cells\,
  which divide\nand differentiate to generate more specialized progeny. The
  mechanisms that\ncontrol the balance between proliferation and differenti
 ation promise\nfundamental insights into the origin and design of multi-ce
 llular\norganisms. However\, stem cells are usually difficult to distingui
 sh from\ntheir more differentiated progeny\, and resolving these mechanism
 s has\nproved challenging. Combining the results of inducible genetic labe
 ling\nstudies from a range of tissue types with concepts from population d
 ynamics\nand statistical physics\, we show how scaling behaviour of clone 
 size\ndistributions reveals signatures of stochastic stem cell fate. As we
 ll as\nproviding insight into the molecular regulatory mechanisms controll
 ing the\nmaintenance\, repair and regeneration of adult tissues\, these re
 sults\nprovide a platform to explore pathways of dysregulation and tumorig
 enesis.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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