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SUMMARY:Perturbation Biology of Cancer Cells - Chris Sander (MSKCC)
DTSTART:20110629T140000Z
DTEND:20110629T150000Z
UID:TALK30705@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:In analogy to perturbation experiments in physics\,\none can s
 ystematically perturb cells\, measure their molecular\nresponse and comput
 ationally infer predictive network models.\nWhen applied to cancer cells\,
  such systems biology models can\nlead to the design of promising combinat
 orial therapies.\n\nThe Cancer Genome Atlas project and the International\
 nCancer Genomics Consortium supply unprecedented\nmolecular profiles of ma
 ny different tumor types. \nThe commonalities and differences in these pro
 files provide\ntwo major therapeutic opportunities: (1) to customize combi
 natorial \ntherapy to the individual and (2) to prevent the emergence \nof
  resistance to single-agent therapies. I will report on\ncomputational and
  cell-line based work in progress in these areas.\n\n
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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