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SUMMARY:The Ras-ERK signalling pathway in striatum-dependent plasticity an
 d diseases - Professor Riccardo Brambilla
DTSTART:20110516T110000Z
DTEND:20110516T120000Z
UID:TALK30751@talks.cam.ac.uk
CONTACT:Shannon Tinley-Browne
DESCRIPTION:Hyperdopaminergic disorders include addictive behaviour in res
 ponse to psychostimulants and L-dopa induced dyskinesia in Parkinsons’s 
 Disease patients. They are characterised by abnormal cellular changes in t
 he basal ganglia system and in particular in the striatum. Among the intra
 cellular signalling cascades that are found altered in these two brain dis
 eases\, the Ras-ERK pathway seems to play a key role in the pathogenesis. 
 Here it will be demonstrated that Ras-GRF1\, as a striatal integrator of d
 opamine and glutamate signals to Ras and ERK\, is not only essential for g
 enerating the abnormal behavioural responses to cocaine but also for produ
 cing motor symptoms associated to chronic L-dopa treatment in animal model
  of Parkinson’s Disease. Experimental evidence supporting a therapeutic 
 approach for these brain diseases based on Ras-ERK inhibition will also be
  provided.
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
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