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SUMMARY:Macrophage paired receptors - structure\, interactions and evoluti
 on - Professor Neil Barclay\, University of Oxford
DTSTART:20110511T113000Z
DTEND:20110511T123000Z
UID:TALK30772@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Paired receptors are families of membrane proteins that have v
 ery similar extracellular regions but different intracellular regions and 
 signalling potential. \n\nThis paradox has been investigated by determinin
 g the fine structure of the members of the SIRP paired receptors family an
 d a ligand CD47. These structures indicate the molecular basis for the fin
 e specificity of SIRP alpha and also to the evolution of antigen receptors
 . The combination of genetic analysis and structural data suggests molecul
 ar mechanisms for how pathogens are driving the rapid evolution of paired 
 receptors and how the environment may be modulating immune responses.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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