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SUMMARY:HIV-1 spread between immune cells - Professor Quentin Sattentau\, 
 University of Oxford
DTSTART:20110615T113000Z
DTEND:20110615T123000Z
UID:TALK30776@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Classically viruses are released from cells as infectious part
 icles which then diffuse in three dimensions through the fluid phase until
  they contact a permissive cell. Although a good strategy for long-distanc
 e viral spread within or between hosts\, this is generally not an efficien
 t infection mechanism. \n\nA faster way to disseminate is via direct viral
  spread between contacting cells. Retroviruses infect leukocytes that have
  no inbuilt polarity and are not stably associated with other cells. In or
 der to spread by contact-dependent mechanisms\, they either have to induce
  cell-cell contact or opportunistically move between cells when they form 
 contacts during their normal physiological function. \n\nOne such opportun
 ity arises when cells form immunological synapses\, and retroviruses appea
 r to hijack this process to form what we and others have termed "virologic
 al synapses". \n\nAnother mode of spread takes place when retrovirally-inf
 ected cells are phagocytosed by macrophages\, resulting in highly efficien
 t macrophage infection. \n\nIn this presentation I will discuss how we thi
 nk HIV-1 moves between cells of the immune system and how this may affect 
 viral pathogenesis.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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