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SUMMARY:Chromatin-mediated regulation of gene expression in mouse ES cells
  - Helle Jørgensen (University of Cambridge)
DTSTART:20111003T150000Z
DTEND:20111003T160000Z
UID:TALK30997@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:  Stem cells have the intrinsic ability to activate a number o
 f  \nalternative gene expression programs in response to inductive signals
   \nwhile maintaining stable expression of the stem cell-specific program 
  \nto ensure self-renewal. The role of transcription factors in  \nmaintai
 ning this balance is well recognised and mounting evidence  \npoints to an
  important role of epigenetic regulation\, consistent with  \nfrequent mut
 ation of epigenetic regulators in developmental disorders  \nand cancer. C
 ompared to somatic cell types\, embryonic stem (ES) cells  \nhave an ‘op
 en’ chromatin structure with a primed configuration at  \ngenes encoding
  key regulators of all three germ layers. This flexible  \nchromatin state
  reflects the wide developmental potential of ES cells  \nand is recreated
  when differentiated cell types are reprogrammed to  \npluripotency. Upon 
 differentiation of ES cells\, epigenetic marks are  \nsubject to wide-spre
 ad redistribution resulting in genome  \ncompartmentalisation. We study ch
 romatin-mediated control of gene  \nexpression in ES cells and during diff
 erentiation in order to  \nunderstand the regulation of mammalian developm
 ent.\n\n\n
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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