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SUMMARY:Intrinsically irregular spiking in a class of cortical inhibitory 
 interneuron - Dr Hugh Robinson\, Dept of Physiology\, Development and Neur
 oscience\, Univ of Cambridge
DTSTART:20110428T150000Z
DTEND:20110428T160000Z
UID:TALK31037@talks.cam.ac.uk
CONTACT:Christian Scheppach
DESCRIPTION:Many neurons in the brain fire quite regularly or periodically
  when excited with a constant stimulus\, and the ability to fire periodica
 lly is important for generating patterns of synchronous oscillation. Hodgk
 in-Huxley type models of voltage-dependent ionic conductances provide a go
 od biophysical understanding of this behaviour.  However\, the dynamics of
  irregular or aperiodic firing in neurons is still poorly understood\, and
  are complicated by the need to distinguish between the variability of the
  synaptic input and intrinsically-generated variability. I will describe o
 ur recent work on a novel type of irregular spiking (IS) inhibitory neuron
  in mammalian neocortex\, in which the irregularity is generated intrinsic
 ally\, and which can synchronise with other IS neurons via specific gap ju
 nctions.  I will describe experiments on the properties and biophysical me
 chanisms of this irregularity\, and propose a computational model which ac
 counts for many of its features.\n\nJoint work with Mariana Vargas-Caballe
 ro and Ole Paulsen.\n
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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