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SUMMARY:From Clone to Clinic- oilseed based bio-pharmaceutical production 
 - Maurice Maloney\, IACR Rothamstead
DTSTART:20111103T160000Z
DTEND:20111103T170000Z
UID:TALK31545@talks.cam.ac.uk
CONTACT:Jill Harrison
DESCRIPTION:Recombinant human Insulin\, including its analogues\, is the l
 argest volume protein pharmaceutical that is manufactured worldwide. It ha
 s a current market value in excess of $8 billion\, with a demand that is g
 rowing due to increasing incidence of Type II diabetes worldwide and the i
 mproved detection of the condition in highly populated\, but underserved c
 ountries. All commercial recombinant insulin is made in microorganisms\, e
 ither in E. coli or yeast. Although the manufacturing process has been gre
 atly streamlined over the past 20 years\, the cost of goods (COGs) is stil
 l a significant factor in supplying the developing world with its necessar
 y supply of Insulin. Furthermore\, the capital cost of a conventional ferm
 entation facility for Insulin is still a major disincentive for constructi
 on in undersupplied countries.  Plants offer the possibility to meet these
  cost constraints in the production of Insulin and the construction of the
  necessary facilities. Plant-based production could decrease the COGs for 
 Insulin by 40-50% and the capital cost of a facility by as much as 70%.  W
 e have used the oilseed plant Safflower as a platform for the expression o
 f a recombinant proinsulin\, which can be recovered inexpensively from the
  seeds using oilbody separation as a key step in the recovery and enrichme
 nt. This approach could allow inexpensive bulk production and purification
  under cGMP conditions. The plant-derived proinsulin is matured into Insul
 in chemically and biochemically identical to commercially available Insuli
 n. We have furthermore shown in human clinical trials that plant-made insu
 lin is bioequivalent to Humulin-R\, a predominant form of insulin prescrib
 ed in N. America. 
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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