BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Functions of Dynamin A\, Myosin IB and WASH in phagolysosome bioge
 nesis\, and the Exocyst in kiss-and-run exocytosis in Dictyostelium - Thie
 rry Soldati\, University of Geneva
DTSTART:20120123T161500Z
DTEND:20120123T180000Z
UID:TALK31586@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Biological processes such as motility and phagocytosis (1) are
  conserved and thus\, their study in the common amoeba Dictyostelium disco
 ideum\, a biochemically and genetically tractable professional phagocyte\,
  is directly relevant to higher organisms. In recent years\, it has become
  a popular model system to study the involvement of the actomyosin cytoske
 leton in vesicle formation and transport in particular during phagolysosom
 e biogenesis. For example\, class I myosins play a variety of roles during
  phagocytic uptake\, membrane retrieval\, phagosome reneutralisation and e
 xocytosis (2). At every stage\, they collaborate with a variety of other m
 olecular machineries\, including actin\, the WASH complex and Dynamin A (3
 \, 4\, 5). In addition\, preparation for exocytosis involves the conserved
  Exocyst complex. The involvement or Rab8a-mediated Exocyst function was b
 est studied during the kiss-and-run discharge of the contractile vacuole s
 ystem.\nIn conclusion\, our investigations of molecular mechanisms of memb
 rane trafficking in Dictyostelium continue to unravel novel roles for many
  highly studied conserved proteins.\n\n(1) Boulais\, J.\, Trost\, M.\, Lan
 dry\, C.\, Dieckmann\, R.\, Levy\, E.\, Soldati\, T.\, Michnick\, S.\, Thi
 bault\, P.\, and Desjardins. M. Molecular characterization of the evolutio
 n of phagosomes. Mol. Syst. Biol. (2010) 6:423 \n(2) Soldati\, T.\, and Sc
 hliwa\, M. Powering membrane traffic in endocytosis and recycling. Nat. Re
 v. Mol. Cell Biol. (2006) 7\, 897-908. \n(3) Gopaldass\, N.\, Patel\, D.\,
  Kratzke\, R.\, Dieckmann\, R.\, Hausherr\, S.\, Hagedorn\, M.\, Neuhaus\,
  E.M.\, Hoffman\, E.\, Hille\, K.\, Kuznetsov\, S.\, and Soldati\, T. Dyna
 min A\, Myosin IB and Abp1 couple phagosome maturation to F-actin binding.
  Traffic (2011) in press. \n(4) Carnell\, M.\, Zech\, T.\, Calaminus\, S.\
 , Ura\, S.\, Hagedorn\, M.\, Johnston\, S.\, May\, R.\, Soldati\, T.\, Mac
 hesky L.\, and Insall R. Actin polymerization driven by WASH causes V-ATPa
 se retrieval and vesicle neutralization before exocytosis J. Cell Biol. (2
 011) 193(5):831-9.\n(5) Dieckmann\, R.\, von Heyden\, SY\, Kistler\, C.\, 
 Gopaldass\, N.\, Hausherr\, S.\, Crawley\, S.W.\, Schwarz\, E\, Diensthube
 r\, R.F.\, Côté\, G.P.\, Tsiavaliaris\, G.\, and Soldati\, T. A myosin I
 K-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency. 
 Mol. Biol. Cell (2010) 21(9):1505-1518. \n
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
END:VEVENT
END:VCALENDAR