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SUMMARY: Autoantibodies against NMDA receptors and other neuronal targets:
  the widening spectrum of antibody-mediated CNS disorders - Angela Vincent
 \, University of Oxford
DTSTART:20110622T133000Z
DTEND:20110622T151500Z
UID:TALK31604@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:\nAutoantibodies against the neuromuscular acetylcholine recep
 tors in myasthenia gravis were first discovered almost 40 years ago\, but 
 the existence of autoantibodies that cause CNS disease has only recently b
 een appreciated.  Three main targets for the autoantibodies are components
  of the voltage-gated potassium channel complex\, LGI1 and CASPR2\,  and N
 MDA receptors.  The diseases are usually quite sudden in  onset with combi
 nations of seizures\, psychiatric and cognitive dysfunction\, and the pati
 ents progress rapidly\, unless treated with immunotherapies to reduce the 
 levels of the antibodies\, although some do improve spontaneously over tim
 e.  Although\, there are many questions outstanding\, current knowledge of
  the cellular targets of the antibodies and the mechanisms involved will b
 e discussed. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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