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SUMMARY:Molecular and cellular mechanisms for memory allocation in neurona
 l networks - Alcino Silva\, UCLA
DTSTART:20110916T151500Z
DTEND:20110916T170000Z
UID:TALK31607@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Although memory allocation is a subject of active research in 
 computer science\, little is known about how the brain allocates informati
 on within neural circuits. Until recently\, however\, the mechanisms that 
 determine how specific cells and synapses (and not their neighbors) within
  a neural circuit are recruited during learning have received little atten
 tion. Recent findings from our laboratory suggest that memory allocation i
 s not random\, but rather specific mechanisms regulate where information i
 s stored within a neural circuit. Our laboratory used a range of single ce
 ll manipulation and recording techniques to demonstrate that CREB activity
  regulates neuronal excitability and consequently the allocation of fear m
 emory to specific cells in lateral amygdala. Our studies suggest that some
  of the mechanisms involved in the consolidation of one memory (e.g.\, CRE
 B activation) affect the allocation of the next memory.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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