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SUMMARY:Modeling non-familial colon cancer susceptibility in mice - David 
 Threadgill\, Department of Genetics\, North Carolina State University
DTSTART:20110714T120000Z
DTEND:20110714T130000Z
UID:TALK31666@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Many mouse models of colorectal cancer (CRC) have been develop
 ed\, but the vast majority model familial forms of cancer. We have been ex
 ploiting a chemical model of colon cancer\, azoxymethane (AOM) exposure\, 
 to model non-familial CRC.  An extensive multi-strain comparison of the re
 sponse to AOM-mediated tumorigenesis suggested genetic contribution to can
 cer\, mirroring non-familial CRC in humans.  We observed significant diffe
 rences in susceptibility and In the present study\, an extensive inbred st
 rain profile was carried out using 39 inbred strains.  A series of F1 and 
 F2 crosses\, and backcrosses between resistant and susceptible inbred stra
 ins in response to AOM showed a wide variety of strain differences in resp
 onse to AOM and detailed analysis of inheritance patterns suggests that re
 sistance to tumor development across populations is inherited in a dominan
 t fashion.  The model also revealed substantial genetic contribution to ca
 ncer morphology. Current studies are underway to identify biomarkers of su
 sceptibility that can be used to identify the likelihood that an individua
 l will develop cancer.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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