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SUMMARY:&quot\;Myeloproliferative neoplasms – JAK/STAT signalling and st
 em cell subversion&quot\; - Prof Tony Green\, University of Cambridge Depa
 rtment of Haematology
DTSTART:20120221T120000Z
DTEND:20120221T130000Z
UID:TALK31750@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:The JAK/STAT pathway plays a key role in stem cell biology and
  is implicated in many human malignancies. A single acquired gain-of-funct
 ion V617F mutation in JAK2 is present in most patients with a myeloprolife
 rative neoplasm (MPN)\, a spectrum of clonal haematological malignancies w
 hich arise in the haematopoietic stem cell compartment.  These disorders a
 re experimentally tractable\, permit clonal analysis and provide a window 
 on the earliest stages of tumorigenesis.  The Green lab is focussing on th
 e pathogenesis of the MPNs and particularly on the molecular and cellular 
 consequences of aberrant JAK/STAT signalling.  Recent highlights of genera
 l relevance for stem cell and cancer biology include unexpected insights i
 nto chromatin biology\, clonal evolution and haematopoietic stem cell func
 tion.
LOCATION:CRI Lecture Theatre
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