BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Embryonic patterning with an oscillating cell population - Dr Andr
 ew Oates\, Max Planck Institute of Molecular Cell Biology and Genetics\, D
 resden\, Germany
DTSTART:20110919T125000Z
DTEND:20110919T131500Z
UID:TALK31852@talks.cam.ac.uk
CONTACT:Duncan Simpson
DESCRIPTION:A population of genetically oscillating cells termed the segme
 ntation clock is hypothesized to control the rhythmic and sequential forma
 tion of vertebrate body segments. Although rhythmically expressed genes ar
 e known\, without mutations that affect the period of the clock\, the role
  of the oscillator was unclear. Using multiple-embryo time-lapse microscop
 y of zebrafish embryos\, we have identified the first segmentation clock p
 eriod mutants. These reveal that the period of the segmentation clock is r
 egulated both at the single-cell level and by intercellular signaling. The
 oretical analysis shows how delays in the coupling between neighboring clo
 ck cells shortens the collective period. Animals with an altered period ha
 ve fewer and longer body segments\, yielding the first direct evidence tha
 t the anatomy of the vertebrate is controlled by an oscillatory mechanism.
  We propose a three-tiered framework for understanding and investigating t
 he segmentation clock as a tissue-level rhythmic pattern generator. \n\nht
 tp://www.imprs-mcbb.de/groupleader/oates.html\n
LOCATION:MR2\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
END:VEVENT
END:VCALENDAR